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Table 3 Spearman correlations between CSF biomarkers, disease duration (years), UPDRS-III, Hoehn and Yahr stage and MMSE in PD

From: Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease

  Disease years UPDRS-III Hoehn and Yahr stage MMSE
t-α-syn 0 · 06 0 · 12 0 · 18 −0 · 46**
p-S129-α-syn 0 · 04 −0 · 16 −0 · 18 −0 · 05
o-α-syn −0 · 25 −0 · 19 −0 · 37* −0 · 01
p-S129/t-α-syn % −0 · 16 −0 · 22 0 · 002 0 · 39**
o/t-α-syn % −0 · 25 −0 · 26 −0 · 31* 0 · 24
  1. Abbreviations: t-α-syn total α-synuclein, p-S129-α-syn phosphorylated Ser 129 α-synuclein, o-α-syn oligomeric α-synuclein, UPDRS- III Unified Parkinson’s Disease Rating Scale-Part-III, H&Y Hoehn and Yahr, MMSE mini-mental state examination. (*p <0.05, **p <0.01, ***p <0.001)