Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease

Table 3 Spearman correlations between CSF biomarkers, disease duration (years), UPDRS-III, Hoehn and Yahr stage and MMSE in PD

	Disease years	UPDRS-III	Hoehn and Yahr stage	MMSE
t-α-syn	0 · 06	0 · 12	0 · 18	−0 · 46**
p-S129-α-syn	0 · 04	−0 · 16	−0 · 18	−0 · 05
o-α-syn	−0 · 25	−0 · 19	−0 · 37*	−0 · 01
p-S129/t-α-syn %	−0 · 16	−0 · 22	0 · 002	0 · 39**
o/t-α-syn %	−0 · 25	−0 · 26	−0 · 31*	0 · 24

Abbreviations: t-α-syn total α-synuclein, p-S129-α-syn phosphorylated Ser 129 α-synuclein, o-α-syn oligomeric α-synuclein, UPDRS- III Unified Parkinson’s Disease Rating Scale-Part-III, H&Y Hoehn and Yahr, MMSE mini-mental state examination. (*p <0.05, **p <0.01, ***p <0.001)

ISSN: 1750-1326