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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells

Fig. 1

Soluble, monomeric Aβ induces a dose-dependent increase in ROS in primary human cerebral VSMC. VSMC were loaded with Mitotracker Red CM-H2XRos (5 μM) and treated with varying concentrations of Aβ1-40 (panel a) or Aβ1-42 (panel b). In some cases, cells were treated with a scrambled control peptide (Aβ40-1) or co-treated with the NADPH oxidase inhibitor apocynin (Apo; 10 μM, panel a-b) or siRNA against Nox2 (panel c) and Aβ. Fluorescence was measured after 30 minutes. Results are representative of 3 independent experiments performed in triplicate. *p < 0.05 vs. vehicle-treated control. #p < 0.05 vs. comparison group

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Molecular Neurodegeneration

ISSN: 1750-1326