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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis

Fig. 1

Schematic diagram of functional domains of the FUS protein with gene mutations identified in patients with ALS are provided. All three patients enrolled in this study have FUS mutations (p.G504Wfs*12, p.R495*, p.Q519E) that affect the NLS region. Q/G/S/Y rich = Gln/Gly/Ser/Tyr-rich domain; RGG = Arg/Gly/Gly-rich motifs; E = nuclear export signal; RRM = RNA-recognition motif; ZnF = zinc-finger motif; L = nuclear localization signal

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Molecular Neurodegeneration

ISSN: 1750-1326