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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo

Fig. 8

Aβ oligomers induce a PrP gain-of-function effect in zebrafish embryonic cells. Levels of AJ proteins (a and b) and SFKs (c-e) in 6 hpf embryonic cells upon treatment with Aβ monomers (m) or oligomers (o). Actin was used as a protein loading control (f). E-cadherin arrowheads as in Fig. 1; arrows = distinct SFKs bands (black: Src/Yes; grey: Fyn). Densitometric analysis of Western blot bands is shown in arbitrary units (AU). Data were collected from three independent experiments (average values ± SEM); statistical significance was assessed using unpaired, two-tailed t-tests, * = p ≤ 0.05, *** = p ≤ 0.001

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Molecular Neurodegeneration

ISSN: 1750-1326