Fig. 1
From: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
ADAMTS-4 expression in the central nervous system. a Differential mRNA expression of ADAMTS proteoglycanases (eg. ADAMTS-1, −4, −5 and −9) in the lumbar spinal cord (SC) and in the cortex of 3-month-old WT male (♂) and female (♀) mice. Ct values are indicated in the histograms. Values plotted are mean ± SEM. Mann–Whitney U-tests: * P < 0.05 compared to ADAMTS-1 expression, $ P < 0.05 compared to ADAMTS-4 expression, # P < 0.05 compared to ADAMTS-5 expression, N = 3-4. b-d Representative photomicrographs of lumbar spinal cord sections from WT mice stained with: ADAMTS-4 (green) and NeuN (neuronal marker, red) (b) ADAMTS-4 (green) and GFAP (astrocyte marker, red) (c) or ADAMTS-4 (green) and APC (oligodendrocyte marker, red) (d). Corresponding Alexa fluor-488 negative controls for ADAMTS-4 (green) in the grey and white matter are shown in e