Fig. 11
From: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
rADAMTS-4 decreases NGF expression in the lumbar spinal cord of male SOD1G93A mice. a Representative photomicrographs of ventral horns in lumbar spinal cord sections from control or ADAMTS-4-treated SOD1G93A male mice stained with NGF. Scale bar: 125 μm. b Quantification of NGF immunoreactivity per area from male mice (a). Values plotted are mean ± SEM. Unpaired two-tailed t-Test: $ P < 0.05 Control Vs ADAMTS-4 SOD1G93A, N = 8 Control SOD1G93A, N = 7 ADAMTS-4 SOD1G93A. c Representative photomicrographs of ventral horns in lumbar spinal cord sections from control or ADAMTS-4-treated SOD1G93A female mice stained with NGF. Scale bar: 125 μm. d Quantification of NGF immunoreactivity per area from female mice (c). Values plotted are mean ± SEM. Unpaired two-tailed t-Test: P > 0.05 Control Vs ADAMTS-4 SOD1G93A, N = 5 Control SOD1G93A, N = 6 ADAMTS-4 SOD1G93A