Fig. 9
From: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
rADAMTS-4 is not toxic to cortical neurons in vitro. Neuronal viability assessed by MTT assay in primary cortical neuron cultures treated or not with a human recombinant ADAMTS-4 (a-b) or ADAMTS-1 (c-d) at different doses (20, 100, 200, 500 ng/ml) 30 min before exposure (b, d) or not (a, c) to glutamate 400 μM (Glu) during 24 h. Values plotted are mean ± SEM. Mann–Whitney U-tests: P > 0.05 control Vs ADAMTS, *** P < 0.001 control Vs glutamate, P > 0.05 glutamate Vs glutamate + ADAMTS, N = 11-12 from 3 independent experiments