Fig. 4
From: Direct α-synuclein promoter transactivation by the tumor suppressor p53
p53 control α-syn transcription in vivo. Analyses of α-syn protein (a) and mRNA levels (b) in control (p53+/+, black bars) or TP53 gene invalidated (p53-/-, white bars) mouse brain as described in the Methods section. Bars represent the means ± SEM of n = 6 (a) or n = 9 animals (b) and are expressed as percentage of control p53+/+ mouse brain samples. Actin expression (a) is provided as protein loading control. Statistical analyses were performed with GraphPad Prism software by using homoscedastic, unpaired Student’s t-test. Significant differences are: **p < 0.01, and ***p < 0.001