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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

Fig. 1

Schematic representation of the proteolytic cleavage of APP by meprin β. We found molecular interaction of APP and the metalloprotease meprin β in the secretory pathway and at the cell surface. On the right site, specific antibodies for APP/APP fragments and their epitopes are marked. Note that the neo-epitope 192wt antibody only recognizes “full-length” sAPPβ having methionine at the C-terminus, while the shorter sAPPβ starting with lysine produced via meprin β cleavage cannot be detected

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Molecular Neurodegeneration

ISSN: 1750-1326