Skip to main content

Table 2 Module assignments for FTD-genes in frontal and temporal cortex

From: Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis

FTD genes Affymetrix ID type Frontal cortex Temporal cortex
module Sz (n) MM 1-q module Sz (n) MM 1-q
MAPT 3723687 pure black 791 0.83 0.03 lightyellow 210 0.67 0.31
GRN 3722917 0.66 0.34 cyan 276 0.56 0.51
CHMP2B 2631845 darkolivegreen 63 0.76 0.48 green 1439 0.53 0.49
HLA-DRA 2903189 darkred ( p  = 0.0046) 141 0.8 0.23 lightcyan ( p  = 0.0139) 250 0.66 0.51
CTSC 3385769 0.73 0.5 0.69 0.47
TMEM106B 2990342 red 925 0.78 0.04 darkturquoise 164 0.86 0.01
C9orf72 3202421 spectrum purple ( p  = 0.0226) 1559 0.74 0.1 purple ( p  = 0.0206) 830 0.75 0.14
VCP 3204404 0.68 0.19 0.71 0.24
UBQLN2 3978999 0.55 0.45 0.63 0.45
OPTN 3235726 0.59 0.38 grey60 220 0.53 0.8
FUS 3656904 lightcyan 209 0.58 0.61 midnightblue 268 0.64 0.31
FUS 3656950 blue 3329 0.31 0.69 pink 2979 0.39 0.58
FUS 3656954 0.5 0.38 magenta 1000 0.44 0.72
TDP-43 2320048 turquoise 4759 0.22 0.89 0.53 0.54
  1. The FTD-genes (with corresponding Affymetrix IDs) are listed. Co-expression modules for the FTD-genes and their relevance within modules are displayed. Sz = size, i.e. number of transcripts contained in the module; MM = module membership; 1-q = 1-quantile of MM. The bolded parts highlight the fact that WGCNA indicated the following: 1) (MAPT and GRN), (HLA-DRA and CTSC), (C9orf72, VCP, UBQLN2 and OPTN) and (2 FUS) transcripts were respectively present in the same modules in frontal cortex, and; 2) (HLA-DRA and CTSC), (C9orf72, VCP and UBQLN2) and (FUS and TARDBP) transcripts were respectively present in the same modules in temporal cortex. The modules containing (HLA-DRA and CTSC) and (C9orf72, VCP, UBQLN2 [and OPTN]) were significantly enriched for FTD transcripts