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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer’s disease

Fig. 3

Analysis of vitamin D3-related dysregulated genes indicates an association with inflammatory response, Alzheimer’s disease and behavior. a Overall, 290 and 249 vitamin D-related DEGs are found misexpressed when comparing vitamin D3-supplemented wild type and transgenic mice with their unsupplemented littermates, respectively. Functional classification of these DEGs show importance of inflammatory, behavioural and Alzheimer’s disease related processes. b qPCR validation of several dysregulated transcripts (n = 6 per group). An overexpression of the transcripts oxytocin (Oxt) and arginine vasopressin (Avp) is confirmed in the cortex as well as an upregulation of estrogen receptor 1 (Esr1) in the hippocampus. The gene coding for lipocalin 2 (Lcn2) is overexpressed in both the hippocampus and the cortex. * = p < 0.05

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Molecular Neurodegeneration

ISSN: 1750-1326