Fig. 1
From: The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
Messenger RNA expression levels of genes within the inflammasome pathway. Expression of 84 genes involved in the inflammasome pathway assessed by real-time quantitative RT-PCR-array in monocytes of individuals with a diagnosis of either severe Alzheimer’s disease (AD), moderate Alzheimer’s disease (MILD) or Mild Cognitive Impairment (MCI) and of age- and sex-matched Healthy Controls (HC). Heat maps of Log2 Fold changes are presented. Results obtained upon stimulating cells with LPS or Aβ42 alone, or upon LPS-priming followed by Aβ42 stimulation are presented. Fold-changes >10 in the expression of LPS + Aβ42 stimulated genes of importance are summarized in the Table