Fig. 2
From: The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
mRNA expression by Real-Time PCR. Single Real-Time PCR results obtained in LPS and Aβ42 -stimulated monocytes of individuals with a diagnosis of either severe Alzheimer’s disease (AD), moderate Alzheimer’s disease (MILD) or Mild Cognitive Impairment (MCI) and of age- and sex-matched Healthy Controls (HC). a NLRP1, NLRP3, caspase 8, PYCARD, caspase 1 and caspase 5 are shown in panel a; IL-1β and IL-18 in panel b and IL-33 and IL-37 in panel c. The results are shown as fold-change expression from the un-stimulated samples. Gene expression was calculated relative to GAPDH housekeeping gene. Summary results are shown in the bar graphs. The boxes stretch from the 25 to the 75 percentile; the line across the boxes indicates the median values; the lines stretching from the boxes indicate extreme values. Outside values are displayed as separate points. Statistical significance is shown *(p <0.05), **(p <0.01)