Fig. 4
From: The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
FACS analyses: co-expression of inflammasome proteins in CD14+ cells. Co-expression of inflammasome proteins in LPS-primed and Aβ42-stimulated CD14+ of individuals with a diagnosis of either severe Alzheimer’s disease (AD), moderate Alzheimer’s disease (MILD) or Mild Cognitive Impairment (MCI) and of age- and sex-matched Healthy Controls (HC). Two-hundred-thousand cells were acquired and gated on CD14 expression and side scatter properties. CD14+ cells co-expressing NLRP3-associated inflammasome components are shown in panel a; CD14+ cells co-expressing NLRP1-associated inflammasome components are shown in panel b. Summary results are shown in the bar graphs. The boxes stretch from the 25° to the 75°percentile; the line across the boxes indicates the median values; the lines stretching from the boxes indicate extreme values. Statistical significance is shown *(p <0.05), **(p <0.01)