Fig. 5
From: The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
Confocal microscopy: co-localization of inflammasome proteins in CD14+ cells. Representative confocal fluorescence images (63× magnification) of experiments (N = 5) showing the effect of LPS-priming and Aβ42-stimulation on NLRP3/PYCARD (a) and NLRP1/caspase 1 (b) co-localization in monocytes of individuals with a diagnosis of either severe Alzheimer’s disease (AD), moderate Alzheimer’s disease (MILD) or Mild Cognitive Impairment (MCI) and of age- and sex-matched Healthy Controls (HC). Summary results of NLRP3/PYCARD and NLRP1/caspase-1 PCC (Pearson co-localization efficiency) are presented in (c) and (d), respectively. The boxes stretch from the 25 to the 75 percentile; the line across the boxes indicates the median values; the lines stretching from the boxes indicate extreme values. Statistical significance is shown *(p <0.05), **(p <0.01)