Fig. 6
From: The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
IL-1β, IL-18, IL-33 and IL-37 production. IL-1β, (panel a), IL-18 (panel b), IL-33 (panel c) and IL-37 (panel d). Interleukin-1β and IL-18 production was assessed by multiplex ELISA in supernatants. CD14+/IL-1β+, CD14+/IL-33 and CD14+/IL-37+ cells were analyzed by flow-cytometry. In both cases, LPS-primed and Aβ42-stimulated monocytes of individuals with a diagnosis of either severe Alzheimer’s disease (AD), moderate Alzheimer’s disease (MILD) or Mild Cognitive Impairment (MCI) and of age- and sex-matched Healthy Controls (HC) were analyzed. Summary results are shown in the bar graphs. The boxes stretch from the 25° to the 75°percentile; the line across the boxes indicates the median values; the lines stretching from the boxes indicate extreme values. Statistical significance is shown *(p <0.05), **(p <0.01)