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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury

Fig. 7

C1q-deficiency delays loss of visual function due to retinal I/R. (a) Representative ERG traces observed in WT mice comparing waveforms from ischemic and uninjured eyes across a series of flash intensities tested 28 days post injury. (b) Comparison of b-wave amplitudes over a 28 day time course at an intensity of 3000 mcd.s/m2. A statistically significant loss of b-wave response was observed in WT (p < 0.01) and C1qa +/- (p < 0.05) ischemic eyes compared to uninjured controls at all time points. However, following initial b-wave suppression, C1qa -/- ischemic eyes displayed a significant rescue (p < 0.05) on day 14. This rescue was transient as a slight decline was observed over the remaining two time points; by the end no statistical differences were observed between any animals receiving ischemic injury. Mean ± SEM, n = 8 per group. *p < 0.05 **p < 0.01 ***p < 0.001 compared to control #p < 0.05 comared to WT–I/R determined by One-way ANOVA followed by Holm-Sidak post test

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