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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Pioglitazone ameliorates the phenotype of a novel Parkinson’s disease mouse model by reducing neuroinflammation

Fig. 5

Cox10 deficient mice display abnormal motor behaviors in response to L-DOPA treatment at 6 months of age. a, d-g Open field test: Cox10/DAT-cre mice show a reduced voluntary movement and decreased rearing activity compared to DAT-cre animals (n = 4), one hour after L-DOPA treatment (25 mg/kg) they show stereotyped movement a, hyperactivity d, e, and decreased resting time g. b Pole test: after L-DOPA treatment, Cox10/DAT-cre mice displayed decreased latencies times when required to descend a pole (n = 4). c: Rotarod test: after L-DOPA treatment Cox10/DAT-cre mice show increased coordination on staying on a rotating rod (n = 4)

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Molecular Neurodegeneration

ISSN: 1750-1326