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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

Fig. 2

C1qa plays a role in dendritic pruning early during glaucoma pathogenesis. We tested whether C1qa has a role in dendrite remodelling using mice deficient in C1qa (D2.C1qa -/-). a Area under the curve (AUC) of the Sholl analysis (at 4 months of age (b), and at 9 months of age (d)) shows a decrease in dendritic complexity in DBA/2 J retinal ganglion cells that is absent in D2.Gpnmb + and D2.C1qa -/- retinas. This is paralleled in both the retinal ganglion cell dendritic field area (c) and total dendritic length (e). Error bars = SEM, ** = P < 0.01, *** = P < 0.001

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