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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

Fig. 5

Ocular hypertensive rat eyes exhibit early inner plexiform layer synapse loss which is absent in C1 inhibitor treated eyes. Administration of a commercial FDA approved C1 inhibitor reduced synapse loss. a Representative images of rat retinas labelled with PSD-95 to show synapses. b Analysis of synaptic density. NT = normotensive eyes, sham control, OHT = ocular hypertensive eyes. Scale bar = 50 μm, * = P < 0.05, *** = P < 0.001, GCL = ganglion cell layer, IPL = inner plexiform layer, INL = inner nuclear layer

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