Fig. 12

Seven-day administration of SP600125 also protected the retina from I/R-induced layer degeneration. SP600125 (15 mg/kg) was administered to retinal I/R injured mice for the first 7 days only. SD-OCT scanning was used to determine progressive changes in whole retinal layer (from NFL to ONL) or each sublayer including IPL, INL and ONL. Images were selected to show layer changes 28 days post I/R injury (a). Progressive changes of whole retinal layer or sub-layers were monitored (b). 7-day administration of SP600125 resulted in protection from retinal layer degeneration induced by I/R injury after 28 day. Open symbols: I/R eyes; closed symbols: un-injured contralateral eyes. Two-way ANOVA analyses indicate that there were no significant time-dependent or injury-dependent changes. (WRL: whole retina layer, IPL: inner plexiform layer, INL: inner nuclear layer, ONL: outer nuclear layer)