Fig. 9

SP600125 ameliorated the I/R-induced reductions in ERG b-wave amplitudes. The a- and b- wave amplitudes of scotopic ERG at 10 cd light intensity were measured in the vehicle and SP600125-treated groups 3, 7, 14, 21, and 28 days after I/R. Data represent mean ± SEM (n = 5). I/R injury induced slight reductions of a-wave amplitudes (a) and significant (p < 0.05) impairment of b waves (b) over 28 days in the vehicle group. In contrast, daily administration of SP600125 prevented impairment of a-waves and b-waves (a and b). Two-way ANOVA analyses indicate that there were no significant time-dependent changes in all SP600125 groups, but significant differences were detected between the control and I/R groups at certain time points (*: p < 0.05 by Bonferroni’s post-hoc test)