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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

Fig. 1

α-Synuclein activates the NLRP3 inflammasome in BV2 cells. a Wide-type and A53T mutants showing α-Syn induces the up-regulation of NLRP3 and Caspase-1 in BV2 cells. Data are presented as the mean ± S.E.M from four independent experiments. b Caspase-1-specific inhibitor (z-YVAD, 10 μM) suppresses IL-1β formation induced by both A53T mutant and wide-type α-Syn. LPS + ATP were used for a positive control drug. Data are presented as the mean ± S.E.M from four independent experiments. c Caspase-1 knockout abolishes WT or A53T α-Syn (10 μg/ml) induced elevation of IL-1β release in primary cultured microglia. d Midbrain TH neurons showed an attenuated impairment and a resistance to condition medium (CM) that was obtained from Caspase-/- microglia treated with WT or A53T α-Syn. Data are presented as the mean ± S.E.M from four independent experiments. * p < 0.05, ** p < 0.01 vs. control group, # p < 0.05, ## p < 0.01 vs. α-Syn treatment group

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