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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

Fig. 6

miR-7 inhibits NLRP3 inflammasome activation and attenuates DA neuronal loss in vivo. Relative miR-7 levels in the serum samples of PD patients (a, n = 12), the midbrain of MPTP-treated mice (b) and A53Ttg/tg mice (c) as well as α-Syn-treated BV2 cells (d). Data are presented as the mean ± S.E.M from four independent experiments. e miR-7 dramatically decreases the activation of IBA-1+ microglia in WT mice treated with MPTP. Scale bar: 150 μm (f-g) miR-7 mimics remarkedly increase the number of TH+ neurons in the SNc of WT mice treated with MPTP. Data are presented as the mean ± S.E.M, n = 6. h-i Injection of miR-7 mimics obviously inhibited NLRP3 inflammasome activation in MPTP-treated mice. j-m Stereotactic injection of miR-7 mimics into the striatum of A53T mice significantly downregulates NLRP3 expression and inhibits production of caspase-1 and IL-1β in vivo. n-o immunostaining showed miR-7 mimics had no significant effect on TH+ cell number in A53Ttg/tg mice at basal state. Data are presented as the mean ± S.E.M, n = 4. * p < 0.05, ** p < 0.01 vs. NC or vehicle group, # p < 0.05, ## p < 0.01 vs MPTP-NC group

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