Fig. 2
From: Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain
The plasma proteome contains disease specific information. To assess the specificity of the proteins identified in the expression level analysis, AD samples were compared to another, unrelated progressive dementia (svPPA = semantic-variant primary progressive aphasia). a Plotting signed, log-transformed p corr-values (more extreme = greater significance) of the AD vs. svPPA analysis show preserved directionality (binominal test) and can be used to categorize proteins into four distinct groups: “General neurodegeneration” (p AD & p svPPA < 0.05, same direction of changes in both diseases; red box); “Non-significant” (p AD & p svPPA > 0.05; green box), “svPPA specific” (p AD > 0.05, p svPPA < 0.05; purple box); “AD specific” (p AD < 0.05, p svPPA > 0.05; yellow box). Venn diagram showing the overlap of significantly changed proteins in AD or svPPA samples (top-left inset; threshold p corr < 0.05; overlap significance by hypergeometric test). b Zooming into the “AD specific” box (see dashed box in a), many proteins can be identified as part of TGFβ/GDF/BMP, complement, or apoptosis signaling in addition to numerous proteins with strong supporting AD literature (manual curation)