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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

Fig. 4

Mutant TauAT worms show aberrant localization of presynaptic components in mechanosensory neurons. a Schematic representation of presynaptic cargo distribution in a normal healthy mechanosensory neuron and a neuron in an aged animal. b Day-1 old worms visualized after crossing them into vdEx262:[Pmec-4::mCherry::rab-3] transgene that expresses mCherry fused to synaptic vesicle associated RAB-3 in mechanosensory neurons. Tauwt-lo and Tauwt-hi show a similar distribution as non-tg reporter strain. TauAT-lo worms show accumulation of mCherry::RAB-3 in the end neuron (yellow arrowhead), cell body (CB, white arrowhead) and posterior neurite (white arrow). By contrast, the mid-neuron of TauAT-lo shows less puncta (6 ± 3 measured per 40 μm length) than non-tg (15 ± 5) and Tauwt-lo (17 ± 6) worms. On day 3, mislocalization of mCherry::RAB-3 worsens in TauAT-lo worms, whereas Tauwt-lo and Tauwt-hi start accumulating mCherry:RAB-3 puncta in the distal axon and posterior neurite (see Additional file 12)

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