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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

Fig. 6

Mutant TauAT worms display abnormal distribution of mitochondria. a Schematic representation of DA9 motor neuron displaying a normal and an abnormal patterning of mitochondria in different compartments (blue dots). b Day-1 old adult worms of the tau-transgenes (left panel) visualized after crossing them into the wyEx2709 [Pitr-1::TOM-20 1-54aa ::yfp] reporter that highlights YFP-tagged mitochondria in DA9 motor neurons. Magnified images of the region corresponding to the proximal axon (boxed area in the schematic) are shown to visualize the faint mitochondrial particles (yellow arrowheads). Mitochondrial particles in day-3 old adult worms of the transgenes (right panel). Areas in white marked by asterisk shows body autofluorescence. c, d, and e Quantification of the average number of mitochondria in different regions of DA9 neurons designated as proximal axon (boxed region), distal axon (away from boxed region) and dendrite. TauAT-lo animals exhibit fewer mitochondria than non-tg and Tauwt worms in all the specified compartments of the neuron at day 1 and day 3. Error bars show mean ± SEM, n ≥ 20. **P ≤ 0.01, ***P ≤ 0.001. Paired t-test with unequal variance was used for comparison

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