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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

Fig. 7

Time-resolved imaging of mitochondria reveals deficits in the trafficking machinery of mutant TauAT animals. a Representative kymographs showing the nature of particle movements in different worm lines. Mitochondria in non-tg, Tauwt-lo and Tauwt-hi worms show long range movements (in the range 8–15 μm) compared to TauAT-lo where mitochondria exhibit short and oscillatory movements (<5 μm). Quantitation of number of mitochondrial trafficking events in proximal (b) and mid region (c) of mechanosensory neuron in day 1 and day 3 adults. TauAT-lo animals show significant reduction in mitochondrial trafficking compared to non-tg and Tauwt-lo both at day 1 and day 3. However, Tauwt showed dose dependent decreasing trends of trafficking events in both the regions of the neuron. Error bars show mean ± SEM, n ≥ 10. **P ≤ 0.001. Paired t-test with unequal variance was used for comparison

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