Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

Table 1 Quantification of GABAergic neuronal damage in day-1 old Tau-tg worms

Strain	VC gaps	DC gaps	N
non-tg	0.4 ± 0.08	0.2 ± 0.14	25
Tau^wt-lo	1.4 ± 0.17^*	1.1 ± 0.09	20
Tau^wt-hi	2.6 ± 0.34^**	1.7 ± 0.71^*	18
Tau^AT-lo	5.8 ± 1.61^***	6.1 ± 1.14^***	24
Tau^AT-hi	6.1 ± 0.98^***	5.5 ± 1.4^***	25

Morphological abnormalities in GABAergic inhibitory neurons apparent as gaps in the dorsal cord (DC gaps) and ventral nerve cord (VC gaps) were assessed with the Punc-25::gfp reporter. N denotes the total number of animals scored per strain. Non-tg worms with Punc-25::gfp reporter serve as controls. P values for statistical significance are derived using ANOVA (Kruskal-Wallis test) (*P < 0.05 vs non-tg, **P < 0.01 vs non-tg, ***P < 0.001 vs non-tg)

ISSN: 1750-1326