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Table 1 Quantification of GABAergic neuronal damage in day-1 old Tau-tg worms

From: Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

Strain VC gaps DC gaps N
non-tg 0.4 ± 0.08 0.2 ± 0.14 25
Tauwt-lo 1.4 ± 0.17* 1.1 ± 0.09 20
Tauwt-hi 2.6 ± 0.34** 1.7 ± 0.71* 18
TauAT-lo 5.8 ± 1.61*** 6.1 ± 1.14*** 24
TauAT-hi 6.1 ± 0.98*** 5.5 ± 1.4*** 25
  1. Morphological abnormalities in GABAergic inhibitory neurons apparent as gaps in the dorsal cord (DC gaps) and ventral nerve cord (VC gaps) were assessed with the Punc-25::gfp reporter. N denotes the total number of animals scored per strain. Non-tg worms with Punc-25::gfp reporter serve as controls. P values for statistical significance are derived using ANOVA (Kruskal-Wallis test) (*P < 0.05 vs non-tg, **P < 0.01 vs non-tg, ***P < 0.001 vs non-tg)
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