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Table 3 Summary of different Tau variant transformations in C. elegans neurons (Toxicity index: %age reduction in thrashes when normalized to non-tg)

From: Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

Strain Sub-cellular localization Phenotype (Unc) Toxicity index
non-tg   Non 0
Full-length (2N4R) hTau40wt-lo Cell bodies and neuronal processes excluding nucleus Weak ~30
Full-length (2N4R) hTau40wt-hi Cell bodies and neuronal processes excluding nucleus Mild ~60
Full-length (2N4R) hTau40AT (lo/hi) Cell bodies and neuronal processes excluding nucleus Strong ~90
Full-length (2N4R) hTau40AT+PP Cell bodies and neuronal processes excluding nucleus Strong ~90
N-terminal hTauwt (Met1-Leu243) Cell bodies and neucleus excluding neuronal processes No obvious phenotype ~13
N-terminal hTauAT (Met1-Leu243) Cell bodies and neucleus excluding neuronal processes No obvious phenotype ~15
  1. Transgenic lines based on different Tau constructs are compared to the non-transgenic control (N2) animals
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