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Table 3 Summary of different Tau variant transformations in C. elegans neurons (Toxicity index: %age reduction in thrashes when normalized to non-tg)

From: Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

Strain

Sub-cellular localization

Phenotype (Unc)

Toxicity index

non-tg

 

Non

0

Full-length (2N4R) hTau40wt-lo

Cell bodies and neuronal processes excluding nucleus

Weak

~30

Full-length (2N4R) hTau40wt-hi

Cell bodies and neuronal processes excluding nucleus

Mild

~60

Full-length (2N4R) hTau40AT (lo/hi)

Cell bodies and neuronal processes excluding nucleus

Strong

~90

Full-length (2N4R) hTau40AT+PP

Cell bodies and neuronal processes excluding nucleus

Strong

~90

N-terminal hTauwt (Met1-Leu243)

Cell bodies and neucleus excluding neuronal processes

No obvious phenotype

~13

N-terminal hTauAT (Met1-Leu243)

Cell bodies and neucleus excluding neuronal processes

No obvious phenotype

~15

  1. Transgenic lines based on different Tau constructs are compared to the non-transgenic control (N2) animals