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Table 6 Gene-based analyses for Mendelian and GWAS PD genes

From: Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson’s Disease

Gene

cMAF PD cases

cMAF controls

P

OR

GBA

0.084

0.034

0.0007

2.28 (1.41–3.68)

LRRK2

0.069

0.034

0.01

1.86 (1.14–3.02)

DJ-1

0.001

0

0.64

2.1 (0.08–52.1)

PARKIN

0.014

0.012

0.96

1.01 (0.43–2.40)

PINK1

0.006

0.005

0.93

1.05 (0.29–3.77)

MAPT

0.005

0.004

0.82

1.17 (0.27–4.95)

  1. Results of SKAT-O analyses including all the validated coding variants were presented. cMAF = cummulative MAF
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Molecular Neurodegeneration

ISSN: 1750-1326