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Table 7 Individuals carrying two rare variants

From: Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson’s Disease

Individual

Ethnicity

AAO

PD FAM HISTORY

Gender

Age at draw

rs#

Variant in GBA

rs#

Second Hit

Both genes

PD Patient

Caucasian

56

NO

F

66

rs71653622

A179T

rs2230288

E365K

GBA and PARK7

Control

Caucasian

NA

NO

F

65

rs421016

L483P

rs1064651

D448H

GBA and GBA

PD Patient

Caucasian

46

NO

F

57

rs76763715

N409S

rs75548401

T408M

GBA and GBA

PD Patient

Caucasian

63

NO

M

77

rs1141812

R83C

rs33995883

N2081D

GBA and LRRK2

PD Patient

Caucasian

82

NO

M

87

rs368060

A495P

rs33995463

L119P

GBA and LRRK2

Control

Caucasian

NA

NO

M

66

rs421016

L483P

rs35658131

Y2189C

GBA and LRRK2

PD Patient

Caucasian

59

YES

F

61

rs76763715

N409S

rs33995883

N2081D

GBA and LRRK2

PD Patient

Caucasian

73

NO

M

75

rs76763715

N409S

rs33995883

N2081D

GBA and LRRK2

Control

Caucasian

NA

NO

F

65

rs368060

A495P

rs34424986

R275W

GBA and PARK2

PD Patient

Caucasian

44

NO

M

50

rs76763715

N409S

rs45478900

G411C

GBA and PINK1