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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

Fig. 1

Aβ42 protofibril deposits are found in glial cells, but not in neurons. Immunocytochemistry of co-cultures containing astrocytes, neurons and oligodendrocytes demonstrates that astrocytes contain large deposits of Aβ42-555 (a). Neurons lack detectable Aβ42-555 levels (b), but the few oligodendrocytes in the culture also contain Aβ42-555 (c). Confocal imaging confirms intracellular localization of large Aβ42-555 inclusions in astrocytes (d). DAPI (blue), GFAP (green) and Aβ42-555 (red). Scale bars: a–c = 20 μm, d = 10 μm

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Molecular Neurodegeneration

ISSN: 1750-1326