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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

Fig. 2

Aβ42 protofibrils accumulate intracellulary in astrocytes over time. Time-lapse images from 30 min to 24 h following Aβ42-555 protofibril administration show that astrocytes (A), but not neurons (*), accumulate Aβ42-555 over time (a). Higher magnification of a highly vascularized astrocyte with ingested Aβ42-555 (b) and a neuron with undetectable levels of intracellular Aβ42-555 (c). Immunohistochemistry of tg-ArcSwe mouse brain sections confirm that Aβ plaques are surrounded by GFAP positive astrocytes, Aβ (red), GFAP (green) and DAPI (blue) (d) and that Aβ are engulfed by astrocytes in vivo (e). Scale bars: a–d = 10 μm

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Molecular Neurodegeneration

ISSN: 1750-1326