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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

Fig. 4

ApoE particles inhibit HSPG-mediated cellular uptake of Aβ in a concentration-dependent manner. CHO-K1 cells or CHO-M1 cells were incubated with Aβ42 (50 nM), together with various concentrations of apoE3 particles (0.2 nM to 200 nM) or apoE4 particles (0.2 nM to 200 nM) for 18 h at 37 °C. The amount of internalized Aβ was quantified by ELISA. Data represent mean ± S.D. (n = 3)

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Molecular Neurodegeneration

ISSN: 1750-1326