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Table 2 Overview of the compounds used in this study

From: Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia

Compound Structure % inhition CK-1δ IC50 [μM] Pe (10−6 cm.s−1) BBB prediction
IGS-2.7 >60 0.023 ± 0.002 11.3 ± 2.0 CNS+
IGS-3.27 >60 0.047 ± 0.005 4.4 ± 2.9 CNS+
  1. The % inhibition of CK-1δ activity was determined in vitro in presence of a fixed concentration of 10 μM of the compounds. IC50: half maximal concentration of both compounds inhibiting CK-1δ activity. Pe: effective permeability (data from PAMPA assay). BBB prediction. Compounds were classified as CNS+ when they present a permeability >3.74 × 10−6 cm · s−1 [20]. Values shown are the mean ± SD