Fig. 2
From: Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice
CUMS successfully induced depression-like behaviors in 3-month-old ApoE-TR mice. a-b Weight change and the percentage of sucrose preference in 3 M ApoE-TR mice during 6 weeks of CUMS. c-d The percentage of time spent and number of entries into the open arms for 3 M ApoE-TR mice in the elevated plus maze test. e-g The extent of locomotion (Horizontal), rearing (Vertical) and total movement (Horizontal + Vertical) for 3 M ApoE-TR mice in the open field test. h The percentage of resting time for 3 M ApoE-TR mice during the 6 min tail suspension test. i Escape latency in 3 M ApoE-TR mice for the first 5 days during the Morris maze test. j The swimming speed of 3 M ApoE-TR mice for the 5 days during the Morris maze test. k-l) The percentage of time spent in target quadrant and the number of times crossing the former platform position during the last day of 3 M ApoE-TR mice in the Morris maze test. m Representative swimming tracks in the Morris water maze for days 1–5 of training and day 6 of probe trial. N = 12 per group, expressed as mean ± SEM. The Figure a, b, i, j used the two-factor ANOVA of statistical methods, and the Figure c-h, k, l used the one-factor ANOVA of statistical methods. & p < 0.05, && p < 0.01, &&& p < 0.001, CUMS E3 vs. Con E3. *p < 0.05, **p < 0.01, ***p < 0.001, CUMS E4 vs. Con E4