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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice

Fig. 3

ApoE4-TR mice recovered from depression but developed cognitive impairment by 12 months old. a-b The percentage of time spent and number of entries into the open arms for 12 M ApoE-TR mice in the elevated plus maze test. c-e The extent of locomotion (Horizontal), rearing (Vertical) and total movement (Horizontal + Vertical) for 12 M ApoE-TR mice in the open field test. f The percentage of resting time for 12 M ApoE-TR mice during the 6 min tail suspension test. g Escape latency of 12 M ApoE-TR mice during the 5 days of training in the Morris maze test. h The swimming speed of 12 M ApoE-TR mice for the first 5 days in the Morris maze test. i-j The percentage of time spent in target quadrant and the number of platform-position crossings for 12 M ApoE-TR mice during the sixth day of the Morris maze test. k Representative swimming tracks in the Morris water maze for days 1–5 of training and day 6 of probe trial. N = 10 per group, expressed as mean ± SEM. The Figure a, -f, i, j and the Figure g, h used the one-factor ANOVA and two-factor ANOVA of statistical methods respectively.*p < 0.05 **p < 0.01, ***p < 0.001, CUMS E4 vs. Con E4. # p < 0.05, ##p < 0.01, ### p < 0.001, CUMS E4 vs. CUMS E3

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