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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

Fig. 1

Levels of AIS cytoskeletal proteins are downregulated in human AD brains and correlate negatively with ac-K274 and ac-K281 tau levels. a Representative images of AnkG immunostaining in human control and AD brains. Scale bars, 10 μm. b, c Representative western blots and quantification of levels of AnkG, βIV-spectrin, ac-K274 tau, and ac-K281 tau in human AD brains. n = 11–15 samples/group. *p < 0.05, **p < 0.01, unpaired t test. d Correlation analyses between AnkG or βIV-spectrin and ac-K274 or ac-K281 tau. Pearson correlation analyses after natural log transformation. Values are mean ± SEM (c)

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Molecular Neurodegeneration

ISSN: 1750-1326