Skip to main content

Table 1 Gene expression profiles of tubulin-binding cofactors in mutant SOD1 motor neurons

From: Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons

Ferraiuolo et al. 2007

Presymptomatic G93A vs. Ctrl (P60)

Symptomatic G93A vs. Ctrl (P90)

Endstage G93A vs. Ctrl (P120)

Gene Symbol

Regulation

Fold-Change

P-Value

Regulation

Fold-Change

P-Value

Regulation

Fold-Change

P-Value

Tbca

up

1,74

1,61 E-01

up

1,13

6,11E-01

down

1,63

9,62E-02

Tbcb

up

1,03

9,24E-01

down

1,08

7,49E-01

down

1,33

6,17E-02

Tbcc

down

1,09

8,24E-01

down

1,25

4,57E-01

up

1,03

9,71E-01

Tbcd

down

1,14

8,10E-01

up

1,07

7,65E-01

down

1,03

9,32E-01

Tbce

up

1,29

6,22E-01

up

1,01

9,87E-01

down

1,07

9,18E-01

Tbcel

down

1,07

9,21 E-01

down

1,12

7,91 E-01

up

1,10

8,09E-01

Nardo et al. 2013

Presymptomatic C57 G93A vs. Ctrl

Onset C57 G93A vs. Ctrl

Symptomatic C57 G93A vs. Ctrl

Gene

Regulation

Fold-Change

P-Value

Regulation

Fold-Change

P-Value

Regulation

Fold-Change

P-Value

Tbca

up

1,23

1,81 E-01

down

1,03

8,53E-01

up

1,04

3,83E-01

Tbcb

up

1,06

7,17E-01

down

1,15

5,21 E-01

down

1,04

8,46E-01

Tbcc

up

1,16

2,81 E-01

down

1,10

2,12E-01

up

1,07

6,83E-01

Tbcd

up

1,09

6,15E-01

up

1,01

9,47E-01

up

1,10

5,20E-01

Tbce

up

1,11

6,02E-01

up

1,17

2,70E-01

up

1,10

1,05E-02

Tbcel

up

1,06

6,01 E-01

up

1,10

4,47E-01

down

1,09

6,51E-01

Nardo et al. 2013

Presymptomatic 129sv G93A vs. Ctrl

Onset 129sv G93A vs. Ctrl

Symptomatic 129sv G93A vs. Ctrl

Gene

Regulation

Fold-Change

P-Value

Regulation

Fold-Change

P-Value

Regulation

Fold-Change

P-Value

Tbca

up

1,11

5,19E-01

down

1,11

2,51 E-01

down

1,10

4,67E-01

Tbcb

up

1,22

2,89E-01

down

1,45

3,00E-03

down

1,45

1,61E-02

Tbcc

up

1,20

1,50E-01

down

1,23

4,28E-02

down

1,06

3,85E-01

Tbcd

up

1,28

1,37E-01

down

1,11

4,26E-01

down

1,06

5,97E-01

Tbce

up

1,17

2,44E-01

down

1,20

8,76E-03

down

1,05

5,69E-01

Tbcel

up

1,10

6,18E-01

up

1,01

9,11E-01

down

1,02

8,61E-01

  1. Gene expression profiles from mutant SOD1 G93A and control motor neurons isolated by laser capture microdissection at different stage of disease [19, 40] respectively were downloaded from the Gene Omnibus database and analyzed with EASANA software based on FAST DB annotations [12, 13]. Gene dysregulation was considered significant at fold changes >1.5 and p-values < 5E-02
  2. Genes encoding tubulin-binding cofactors Tbca to Tbcel are not significantly dys-regulated in mutant SOD1 motor neurons at any time point in the datasets GSE10953 [19] or GSE46298 [40]
  3. Note that mutant SOD1 G93A mice with genetic backgrounds C57BL/6 or 129sv and corresponding control mice were analyzed in the study of Nardo and colleagues [40]. Here, onset of disease was defined when mice showed first signs of paw grip strength impairment and when body weight started to decline. Symptomatic disease was defined when mice displayed a decrease of 50 % in their latency on grip strength and when body weight declined by >5 %
Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326