Table 2 Gene expression profiles of Stathmins in mutant SOD1 motor neurons
From: Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons
Ferraiuolo et al. 2007 | Presymptomatic G93A vs. Ctrl (P60) | Symptomatic G93A vs. Ctrl (P90) | Endstage G93A vs. Ctrl (P120) | ||||||
Gene | Regulation | Fold-Change | P-Value | Regulation | Fold-Change | P-Value | Regulation | Fold-Change | P-Value |
Stmnl | up | 1,87 | 3,80E-02 | up | 1,21 | 4,54E-01 | down | 1,40 | 3,32E-01 |
Stmn2 | down | 1,03 | 9,47E-01 | down | 1,39 | 2,65E-01 | up | 1,91 | 3,96E-01 |
Stmn3 | down | 1,71 | 9,50E-03 | down | 1,44 | 2,73E-01 | down | 1,21 | 2,92E-01 |
Stmn4 | down | 1,02 | 9,61 E-01 | up | 1,39 | 5,15E-01 | up | 1,09 | 8,50E-01 |
Nardo et al. 2013 | Presymptomatic C57 G93A vs. Ctrl | Onset C57 G93A vs. Ctrl | Symptomatic C57 G93A vs. Ctrl | ||||||
Gene | Regulation | Fold-Change | P-Value | Regulation | Fold-Change | P-Value | Regulation | Fold-Change | P-Value |
Stmnl | down | 1,35 | 9,31 E-02 | up | 1,17 | 1,49E-01 | up | 1,16 | 3,48E-01 |
Stmn2 | down | 1,05 | 8.98E-01 | down | 1,52 | 2,38E-01 | up | 1,36 | 4,89E-01 |
Stmn3 | up | 1,07 | 7.28E-01 | down | 1,24 | 1,41 E-02 | down | 1,14 | 1,50E-02 |
Stmn4 | down | 1,06 | 6,69E-01 | up | 1,43 | 1,63E-01 | up | 1,36 | 3,15E-02 |
Nardo et al. 2013 | Presymptomatic 129v G93A vs. Ctr | Onset 129sv G93A vs. Ctrl | Symptomatic 129sv G93A vs. Ctrl | ||||||
Gene | Regulation | Fold-Change | P-Value | Regulation | Fold-Change | P-Value | Regulation | Fold-Change | P-Value |
Stmnl | up | 1,05 | 5,50E-01 | up | 1,06 | 3,40E-01 | down | 1,04 | 7,57E-01 |
Stmn2 | up | 1,63 | 1.98E-02 | down | 1,46 | 1,76E-01 | down | 1,71 | 9,08E-02 |
Stmn3 | up | 1,08 | 6,24E-01 | down | 1,25 | 6,38E-03 | down | 1,30 | 1,18E-02 |
Stmn4 | down | 1,13 | 3,75E-01 | up | 1,15 | 3,11E-01 | up | 1,23 | 2,98E-03 |
Perrin et al. 2006 | Presymptomatic G93A vs. Ctrl (P60) | Symptomatic G93A vs. Ctrl (P90) | Endstage G93A vs. Ctrl (P120) | ||||||
Gene | Regulation | Fold-Change | P-Value | Regulation | Fold-Change | P-Value | Regulation | Fold-Change | P-Value |
Stmnl | down | 1,38 | nc | down | 1,38 | nc | up | 1,68 | 6,00E-02 |
Stmn2 | up | 1,20 | nc | up | 1,30 | 1,36E-01 | up | 1,12 | 6,44E-01 |
Stmn3 | down | 1,03 | nc | up | 1,07 | 5,63E-01 | down | 1,02 | 8,36E-01 |
Stmn4 | up | 1,75 | nc | up | 1,30 | 6,49E-01 | up | 1,85 | nc |