Fig. 2
From: Redundant Gs-coupled serotonin receptors regulate amyloid-β metabolism in vivo
Inhibiting 5-HT4R and 5-HT7R simultaneously increases ISF Aβ. Selective 5-HT4R antagonist GR113808 (100 nM), selective 5-HT7R antagonist SB258719 (3.16 μM), both antagonists together, or DMSO vehicle were infused via reverse microdialysis in 2.5 month old APP/PS1 hemizygous mice for 8 h. a As assayed by microdialysis, treatment with GR113808 or SB258719 alone had no detectable effect on ISF Aβx-40 (n = 4), but co-administration of both antagonists increased ISF Aβx-40. b 24 h of treatment with both antagonists significantly increased ISF Aβx-40 to 132 ± 11.2 % (p = 0.048, n = 10) by 21–24 h. Data presented as mean ± SEM. Asterisks mark p-values < 0.05