Fig. 6From: Redundant Gs-coupled serotonin receptors regulate amyloid-β metabolism in vivoModel of Aβ reduction by serotonergic signaling. Serotonin binding to 5-HT4R, 5-HT6R, and 5-HT7R leads to the activation of PKA. PKA subsequently activates the MEK and ERK cascade. Activated ERK remains in the cytoplasm and phosphorylates α-secretase to increase its activity and reduce Aβ productionBack to article page