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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia

Fig. 3

Trehalose increases PGRN expression via increased transcription. a GRN mRNA levels were quantified from H4 cells after treatment with 0, 50, or 100 mM trehalose for 18 h (n = 2 independent experiments run in duplicates). The bars represent the mean ± SEM. **Differs from control, P < 0.01 using one-way ANOVA followed by Dunnett’s comparison post-hoc test. b Immunoblot of cell lysates from H4 cells treated with trehalose (100 mM) plus actinomycin D (1 μM) overnight (16 h) to block new transcription. Results are representative of two independent experiments

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