TY - JOUR AU - Ferri, C. P. AU - Prince, M. AU - Brayne, C. AU - Brodaty, H. AU - Fratiglioni, L. AU - Ganguli, M. PY - 2005 DA - 2005// TI - Global prevalence of dementia: a Delphi consensus study JO - Lancet VL - 366 UR - https://doi.org/10.1016/S0140-6736(05)67889-0 DO - 10.1016/S0140-6736(05)67889-0 ID - Ferri2005 ER - TY - STD TI - Prince M, Wimo A, Guerchet M, Ali G, Wu Y, Prina M, et al. World Alzheimer Report 2015, The Global Impact of Dementia: An analysis of prevalence, incidence, cost and trends ID - ref2 ER - TY - JOUR AU - Hardy, J. AU - Selkoe, D. J. PY - 2002 DA - 2002// TI - The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics JO - Science VL - 297 UR - https://doi.org/10.1126/science.1072994 DO - 10.1126/science.1072994 ID - Hardy2002 ER - TY - JOUR AU - Pedersen, N. L. AU - Gatz, M. AU - Berg, S. AU - Johansson, B. PY - 2004 DA - 2004// TI - How heritable is Alzheimer’s disease late in life? Findings from Swedish twins JO - Ann Neurol VL - 55 UR - https://doi.org/10.1002/ana.10999 DO - 10.1002/ana.10999 ID - Pedersen2004 ER - TY - JOUR AU - Selkoe, D. J. PY - 2001 DA - 2001// TI - Alzheimer’s disease: genes, proteins, and therapy JO - Physiol Rev VL - 81 ID - Selkoe2001 ER - TY - JOUR AU - Miravalle, L. AU - Calero, M. AU - Takao, M. AU - Roher, A. E. AU - Ghetti, B. AU - Vidal, R. PY - 2005 DA - 2005// TI - Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques JO - Biochemistry VL - 44 UR - https://doi.org/10.1021/bi0508237 DO - 10.1021/bi0508237 ID - Miravalle2005 ER - TY - JOUR AU - Mullan, M. AU - Crawford, F. AU - Axelman, K. AU - Houlden, H. AU - Lilius, L. AU - Winblad, B. PY - 1992 DA - 1992// TI - A pathogenic mutation for probable Alzheimer’s disease in the APP gene at the N-terminus of beta-amyloid JO - Nat Genet VL - 1 UR - https://doi.org/10.1038/ng0892-345 DO - 10.1038/ng0892-345 ID - Mullan1992 ER - TY - JOUR AU - Wisniewski, T. AU - Dowjat, W. K. AU - Buxbaum, J. D. AU - Khorkova, O. AU - Efthimiopoulos, S. AU - Kulczycki, J. PY - 1998 DA - 1998// TI - A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer’s disease and leads to death as early as the age of 28 years JO - Neuroreport VL - 9 UR - https://doi.org/10.1097/00001756-199801260-00008 DO - 10.1097/00001756-199801260-00008 ID - Wisniewski1998 ER - TY - JOUR AU - Kang, J. AU - Lemaire, H. G. AU - Unterbeck, A. AU - Salbaum, J. M. AU - Masters, C. L. AU - Grzeschik, K. H. PY - 1987 DA - 1987// TI - The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor JO - Nature VL - 325 UR - https://doi.org/10.1038/325733a0 DO - 10.1038/325733a0 ID - Kang1987 ER - TY - JOUR AU - Wolfe, M. S. PY - 2006 DA - 2006// TI - The gamma-secretase complex: membrane-embedded proteolytic ensemble JO - Biochemistry VL - 45 UR - https://doi.org/10.1021/bi060799c DO - 10.1021/bi060799c ID - Wolfe2006 ER - TY - JOUR AU - Vassar, R. AU - Bennett, B. D. AU - Babu-Khan, S. AU - Kahn, S. AU - Mendiaz, E. A. AU - Denis, P. PY - 1999 DA - 1999// TI - Beta-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE JO - Science VL - 286 UR - https://doi.org/10.1126/science.286.5440.735 DO - 10.1126/science.286.5440.735 ID - Vassar1999 ER - TY - JOUR AU - Wolfe, M. S. PY - 2012 DA - 2012// TI - Processive proteolysis by γ-secretase and the mechanism of Alzheimer’s disease JO - Biol Chem VL - 393 UR - https://doi.org/10.1515/hsz-2012-0140 DO - 10.1515/hsz-2012-0140 ID - Wolfe2012 ER - TY - JOUR AU - Mori, H. AU - Takio, K. AU - Ogawara, M. AU - Selkoe, D. J. PY - 1992 DA - 1992// TI - Mass spectrometry of purified amyloid beta protein in Alzheimer’s disease JO - J Biol Chem VL - 267 ID - Mori1992 ER - TY - JOUR AU - Huse, J. T. AU - Liu, K. AU - Pijak, D. S. AU - Carlin, D. AU - Lee, V. M. AU - Doms, R. W. PY - 2002 DA - 2002// TI - Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer’s disease brain JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M111141200 DO - 10.1074/jbc.M111141200 ID - Huse2002 ER - TY - JOUR AU - Gruninger-Leitch, F. AU - Schlatter, D. AU - Kung, E. AU - Nelbock, P. AU - Dobeli, H. PY - 2002 DA - 2002// TI - Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M109266200 DO - 10.1074/jbc.M109266200 ID - Gruninger-Leitch2002 ER - TY - JOUR AU - Glenner, G. G. AU - Wong, C. W. PY - 1984 DA - 1984// TI - Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein JO - Biochem Biophys Res Commun VL - 120 UR - https://doi.org/10.1016/S0006-291X(84)80190-4 DO - 10.1016/S0006-291X(84)80190-4 ID - Glenner1984 ER - TY - JOUR AU - Masters, C. L. AU - Simms, G. AU - Weinman, N. A. AU - Multhaup, G. AU - McDonald, B. L. AU - Beyreuther, K. PY - 1985 DA - 1985// TI - Amyloid plaque core protein in Alzheimer disease and Down syndrome JO - Proc Natl Acad Sci U S A VL - 82 UR - https://doi.org/10.1073/pnas.82.12.4245 DO - 10.1073/pnas.82.12.4245 ID - Masters1985 ER - TY - JOUR AU - Selkoe, D. J. AU - Abraham, C. R. AU - Podlisny, M. B. AU - Duffy, L. K. PY - 1986 DA - 1986// TI - Isolation of Low-Molecular-Weight Proteins from Amyloid Plaque Fibers in Alzheimer’s Disease JO - J Neurochem VL - 46 UR - https://doi.org/10.1111/j.1471-4159.1986.tb08501.x DO - 10.1111/j.1471-4159.1986.tb08501.x ID - Selkoe1986 ER - TY - JOUR AU - Saido, T. C. AU - Iwatsubo, T. AU - Mann, D. M. AU - Shimada, H. AU - Ihara, Y. AU - Kawashima, S. PY - 1995 DA - 1995// TI - Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques JO - Neuron VL - 14 UR - https://doi.org/10.1016/0896-6273(95)90301-1 DO - 10.1016/0896-6273(95)90301-1 ID - Saido1995 ER - TY - JOUR AU - Kawarabayashi, T. AU - Younkin, L. H. AU - Saido, T. C. AU - Shoji, M. AU - Ashe, K. H. AU - Younkin, S. G. PY - 2001 DA - 2001// TI - Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer’s disease JO - J Neurosci VL - 21 ID - Kawarabayashi2001 ER - TY - JOUR AU - Schilling, S. AU - Zeitschel, U. AU - Hoffmann, T. AU - Heiser, U. AU - Francke, M. AU - Kehlen, A. PY - 2008 DA - 2008// TI - Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer’s disease-like pathology JO - Nat Med VL - 14 UR - https://doi.org/10.1038/nm.1872 DO - 10.1038/nm.1872 ID - Schilling2008 ER - TY - JOUR AU - Guntert, A. AU - Dobeli, H. AU - Bohrmann, B. PY - 2006 DA - 2006// TI - High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain JO - Neuroscience VL - 143 UR - https://doi.org/10.1016/j.neuroscience.2006.08.027 DO - 10.1016/j.neuroscience.2006.08.027 ID - Guntert2006 ER - TY - JOUR AU - Frost, J. L. AU - Le, K. X. AU - Cynis, H. AU - Ekpo, E. AU - Kleinschmidt, M. AU - Palmour, R. M. PY - 2013 DA - 2013// TI - Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models JO - Am J Pathol VL - 183 UR - https://doi.org/10.1016/j.ajpath.2013.05.005 DO - 10.1016/j.ajpath.2013.05.005 ID - Frost2013 ER - TY - JOUR AU - Schilling, S. AU - Hoffmann, T. AU - Manhart, S. AU - Hoffmann, M. AU - Demuth, H. U. PY - 2004 DA - 2004// TI - Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions JO - FEBS Lett VL - 563 UR - https://doi.org/10.1016/S0014-5793(04)00300-X DO - 10.1016/S0014-5793(04)00300-X ID - Schilling2004 ER - TY - JOUR AU - Schilling, S. AU - Manhart, S. AU - Hoffmann, T. AU - Ludwig, H. H. AU - Wasternack, C. AU - Demuth, H. U. PY - 2003 DA - 2003// TI - Substrate specificity of glutaminyl cyclases from plants and animals JO - Biol Chem VL - 384 UR - https://doi.org/10.1515/BC.2003.175 DO - 10.1515/BC.2003.175 ID - Schilling2003 ER - TY - JOUR AU - Seifert, F. AU - Schulz, K. AU - Koch, B. AU - Manhart, S. AU - Demuth, H. AU - Schilling, S. PY - 2009 DA - 2009// TI - Glutaminyl cyclases display significant catalytic proficiency for glutamyl substrates JO - Biochemistry VL - 48 UR - https://doi.org/10.1021/bi9018835 DO - 10.1021/bi9018835 ID - Seifert2009 ER - TY - JOUR AU - Sevalle, J. AU - Amoyel, A. AU - Robert, P. AU - Fournié-Zaluski, M. AU - Roques, B. AU - Checler, F. PY - 2009 DA - 2009// TI - Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide JO - J Neurochem VL - 109 UR - https://doi.org/10.1111/j.1471-4159.2009.05950.x DO - 10.1111/j.1471-4159.2009.05950.x ID - Sevalle2009 ER - TY - JOUR AU - Citron, M. AU - Diehl, T. AU - Capell, A. AU - Haass, C. AU - Teplow, D. AU - Selkoe, D. PY - 1996 DA - 1996// TI - Inhibition of Amyloid β-Protein Production in Neural Cells by the Serine Protease Inhibitor AEBSF JO - Neuron VL - 17 UR - https://doi.org/10.1016/S0896-6273(00)80290-1 DO - 10.1016/S0896-6273(00)80290-1 ID - Citron1996 ER - TY - JOUR AU - Citron, M. AU - Teplow, D. B. AU - Selkoe, D. J. PY - 1995 DA - 1995// TI - Generation of amyloid β protein from its precursor is sequence specific JO - Neuron VL - 14 UR - https://doi.org/10.1016/0896-6273(95)90323-2 DO - 10.1016/0896-6273(95)90323-2 ID - Citron1995 ER - TY - JOUR AU - Citron, M. AU - Vigo-Pelfrey, C. AU - Teplow, D. B. AU - Miller, C. AU - Schenk, D. AU - Johnston, J. AU - Winblad, B. AU - Venizelos, N. AU - Lannfelt, L. AU - Selkoe, D. J. PY - 1994 DA - 1994// TI - Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation JO - Proc Natl Acad Sci U S A VL - 91 UR - https://doi.org/10.1073/pnas.91.25.11993 DO - 10.1073/pnas.91.25.11993 ID - Citron1994 ER - TY - JOUR AU - Cynis, H. AU - Scheel, E. AU - Saido, T. C. AU - Schilling, S. AU - Demuth, H. PY - 2008 DA - 2008// TI - Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta JO - Biochemistry VL - 47 UR - https://doi.org/10.1021/bi800250p DO - 10.1021/bi800250p ID - Cynis2008 ER - TY - JOUR AU - Schlenzig, D. AU - Manhart, S. AU - Cinar, Y. AU - Kleinschmidt, M. AU - Hause, G. AU - Willbold, D. PY - 2009 DA - 2009// TI - Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides JO - Biochemistry VL - 48 UR - https://doi.org/10.1021/bi900818a DO - 10.1021/bi900818a ID - Schlenzig2009 ER - TY - JOUR AU - Schlenzig, D. AU - Rönicke, R. AU - Cynis, H. AU - Ludwig, H. AU - Scheel, E. AU - Reymann, K. PY - 2012 DA - 2012// TI - N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation JO - J Neurochem VL - 121 UR - https://doi.org/10.1111/j.1471-4159.2012.07707.x DO - 10.1111/j.1471-4159.2012.07707.x ID - Schlenzig2012 ER - TY - JOUR AU - Nussbaum, J. M. AU - Schilling, S. AU - Cynis, H. AU - Silva, A. AU - Swanson, E. AU - Wangsanut, T. PY - 2012 DA - 2012// TI - Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β JO - Nature VL - 485 UR - https://doi.org/10.1038/nature11060 DO - 10.1038/nature11060 ID - Nussbaum2012 ER - TY - JOUR AU - Russo, C. AU - Violani, E. AU - Salis, S. AU - Venezia, V. AU - Dolcini, V. AU - Damonte, G. PY - 2002 DA - 2002// TI - Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival JO - J Neurochem VL - 82 UR - https://doi.org/10.1046/j.1471-4159.2002.01107.x DO - 10.1046/j.1471-4159.2002.01107.x ID - Russo2002 ER - TY - JOUR AU - Alexandru, A. AU - Jagla, W. AU - Graubner, S. AU - Becker, A. AU - Bäuscher, C. AU - Kohlmann, S. PY - 2011 DA - 2011// TI - Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation JO - J Neurosci VL - 31 UR - https://doi.org/10.1523/JNEUROSCI.1794-11.2011 DO - 10.1523/JNEUROSCI.1794-11.2011 ID - Alexandru2011 ER - TY - JOUR AU - Wirths, O. AU - Breyhan, H. AU - Cynis, H. AU - Schilling, S. AU - Demuth, H. AU - Bayer, T. A. PY - 2009 DA - 2009// TI - Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model JO - Acta Neuropathol VL - 118 UR - https://doi.org/10.1007/s00401-009-0557-5 DO - 10.1007/s00401-009-0557-5 ID - Wirths2009 ER - TY - JOUR AU - McGowan, E. AU - Pickford, F. AU - Kim, J. AU - Onstead, L. AU - Eriksen, J. AU - Yu, C. PY - 2005 DA - 2005// TI - Abeta42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice JO - Neuron VL - 47 UR - https://doi.org/10.1016/j.neuron.2005.06.030 DO - 10.1016/j.neuron.2005.06.030 ID - McGowan2005 ER - TY - JOUR AU - Kim, J. AU - Onstead, L. AU - Randle, S. AU - Price, R. AU - Smithson, L. AU - Zwizinski, C. PY - 2007 DA - 2007// TI - Abeta40 inhibits amyloid deposition in vivo JO - J Neurosci VL - 27 UR - https://doi.org/10.1523/JNEUROSCI.4849-06.2007 DO - 10.1523/JNEUROSCI.4849-06.2007 ID - Kim2007 ER - TY - JOUR AU - Lee, J. AU - Gillman, A. L. AU - Jang, H. AU - Ramachandran, S. AU - Kagan, B. L. AU - Nussinov, R. PY - 2014 DA - 2014// TI - Role of the fast kinetics of pyroglutamate-modified amyloid-β oligomers in membrane binding and membrane permeability JO - Biochemistry VL - 53 UR - https://doi.org/10.1021/bi500587p DO - 10.1021/bi500587p ID - Lee2014 ER - TY - JOUR AU - Gillman, A. L. AU - Jang, H. AU - Lee, J. AU - Ramachandran, S. AU - Kagan, B. L. AU - Nussinov, R. PY - 2014 DA - 2014// TI - Activity and Architecture of Pyroglutamate Modified Amyloid-β (AβpE3-42) Pores//Activity and architecture of pyroglutamate-modified amyloid-β (AβpE3-42) pores JO - J Phys Chem B VL - 118 UR - https://doi.org/10.1021/jp5040954 DO - 10.1021/jp5040954 ID - Gillman2014 ER - TY - JOUR AU - Gunn, A. P. AU - Wong, B. X. AU - Johanssen, T. AU - Griffith, J. C. AU - Masters, C. L. AU - Bush, A. I. PY - 2016 DA - 2016// TI - Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons JO - J Biol Chem VL - 291 UR - https://doi.org/10.1074/jbc.M115.655183 DO - 10.1074/jbc.M115.655183 ID - Gunn2016 ER - TY - JOUR AU - Schenk, D. AU - Barbour, R. AU - Dunn, W. AU - Gordon, G. AU - Grajeda, H. AU - Guido, T. PY - 1999 DA - 1999// TI - Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse JO - Nature VL - 400 UR - https://doi.org/10.1038/22124 DO - 10.1038/22124 ID - Schenk1999 ER - TY - JOUR AU - Lemere, C. A. AU - Masliah, E. PY - 2010 DA - 2010// TI - Can Alzheimer disease be prevented by amyloid-beta immunotherapy? JO - Nat Rev Neurol VL - 6 UR - https://doi.org/10.1038/nrneurol.2009.219 DO - 10.1038/nrneurol.2009.219 ID - Lemere2010 ER - TY - JOUR AU - Boche, D. AU - Denham, N. AU - Holmes, C. AU - Nicoll, J. A. PY - 2010 DA - 2010// TI - Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer’s disease pathogenesis JO - Acta Neuropathol VL - 120 UR - https://doi.org/10.1007/s00401-010-0719-5 DO - 10.1007/s00401-010-0719-5 ID - Boche2010 ER - TY - JOUR AU - Gilman, S. AU - Koller, M. AU - Black, R. S. AU - Jenkins, L. AU - Griffith, S. G. AU - Fox, N. C. PY - 2005 DA - 2005// TI - Clinical effects of A immunization (AN1792) in patients with AD in an interrupted trial JO - Neurology VL - 64 UR - https://doi.org/10.1212/01.WNL.0000159740.16984.3C DO - 10.1212/01.WNL.0000159740.16984.3C ID - Gilman2005 ER - TY - JOUR AU - Monsonego, A. AU - Imitola, J. AU - Zota, V. AU - Oida, T. AU - Weiner, H. L. PY - 2003 DA - 2003// TI - Microglia-Mediated Nitric Oxide Cytotoxicity of T Cells Following Amyloid -Peptide Presentation to Th1 Cells JO - J Immunol VL - 171 UR - https://doi.org/10.4049/jimmunol.171.5.2216 DO - 10.4049/jimmunol.171.5.2216 ID - Monsonego2003 ER - TY - JOUR AU - Cribbs, D. H. PY - 2003 DA - 2003// TI - Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid JO - Int Immunol VL - 15 UR - https://doi.org/10.1093/intimm/dxg049 DO - 10.1093/intimm/dxg049 ID - Cribbs2003 ER - TY - JOUR AU - Pride, M. AU - Seubert, P. AU - Grundman, M. AU - Hagen, M. AU - Eldridge, J. AU - Black, R. S. PY - 2008 DA - 2008// TI - Progress in the active immunotherapeutic approach to Alzheimer’s disease: clinical investigations into AN1792-associated meningoencephalitis JO - Neurodegener Dis VL - 5 UR - https://doi.org/10.1159/000113700 DO - 10.1159/000113700 ID - Pride2008 ER - TY - JOUR AU - Holmes, C. AU - Boche, D. AU - Wilkinson, D. AU - Yadegarfar, G. AU - Hopkins, V. AU - Bayer, A. PY - 2008 DA - 2008// TI - Long-term effects of Aβ42 immunisation in Alzheimer’s disease: follow-up of a randomised, placebo-controlled phase I trial JO - Lancet VL - 372 UR - https://doi.org/10.1016/S0140-6736(08)61075-2 DO - 10.1016/S0140-6736(08)61075-2 ID - Holmes2008 ER - TY - JOUR AU - Ryan, J. M. AU - Grundman, M. PY - 2009 DA - 2009// TI - Anti-amyloid-beta immunotherapy in Alzheimer’s disease: ACC-001 clinical trials are ongoing JO - J Alzheimers Dis VL - 17 ID - Ryan2009 ER - TY - JOUR AU - Arai, H. AU - Suzuki, H. AU - Yoshiyama, T. PY - 2015 DA - 2015// TI - Vanutide Cridificar and the QS-21 Adjuvant in Japanese Subjects with Mild to Moderate Alzheimer’ s Disease: Results from Two Phase 2 Studies JO - CAR VL - 12 UR - https://doi.org/10.2174/1567205012666150302154121 DO - 10.2174/1567205012666150302154121 ID - Arai2015 ER - TY - JOUR AU - Winblad, B. AU - Andreasen, N. AU - Minthon, L. AU - Floesser, A. AU - Imbert, G. AU - Dumortier, T. PY - 2012 DA - 2012// TI - Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer’s disease: randomised, double-blind, placebo-controlled, first-in-human study JO - Lancet Neurol VL - 11 UR - https://doi.org/10.1016/S1474-4422(12)70140-0 DO - 10.1016/S1474-4422(12)70140-0 ID - Winblad2012 ER - TY - JOUR AU - Farlow, M. R. AU - Andreasen, N. AU - Riviere, M. AU - Vostiar, I. AU - Vitaliti, A. AU - Sovago, J. PY - 2015 DA - 2015// TI - Long-term treatment with active Aβ immunotherapy with CAD106 in mild Alzheimer’s disease JO - Alzheimers Res Ther VL - 7 UR - https://doi.org/10.1186/s13195-015-0108-3 DO - 10.1186/s13195-015-0108-3 ID - Farlow2015 ER - TY - JOUR AU - Schneeberger, A. AU - Mandler, M. AU - Otawa, O. AU - Zauner, W. AU - Mattner, F. AU - Schmidt, W. PY - 2009 DA - 2009// TI - Development of AFFITOPE vaccines for Alzheimer’s disease (AD)--from concept to clinical testing JO - J Nutr Health Aging VL - 13 UR - https://doi.org/10.1007/s12603-009-0070-5 DO - 10.1007/s12603-009-0070-5 ID - Schneeberger2009 ER - TY - JOUR AU - Johnson-Wood, K. AU - Lee, M. AU - Motter, R. AU - Hu, K. AU - Gordon, G. AU - Barbour, R. PY - 1997 DA - 1997// TI - Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease JO - Proc Natl Acad Sci U S A VL - 94 UR - https://doi.org/10.1073/pnas.94.4.1550 DO - 10.1073/pnas.94.4.1550 ID - Johnson-Wood1997 ER - TY - JOUR AU - Salloway, S. AU - Sperling, R. AU - Gilman, S. AU - Fox, N. C. AU - Blennow, K. AU - Raskind, M. PY - 2009 DA - 2009// TI - A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease JO - Neurology VL - 73 UR - https://doi.org/10.1212/WNL.0b013e3181c67808 DO - 10.1212/WNL.0b013e3181c67808 ID - Salloway2009 ER - TY - JOUR AU - Rinne, J. O. AU - Brooks, D. J. AU - Rossor, M. N. AU - Fox, N. C. AU - Bullock, R. AU - Klunk, W. E. PY - 2010 DA - 2010// TI - 11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer’s disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study//11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer’s disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study JO - Lancet Neurol VL - 9 UR - https://doi.org/10.1016/S1474-4422(10)70043-0 DO - 10.1016/S1474-4422(10)70043-0 ID - Rinne2010 ER - TY - JOUR AU - Roher, A. E. AU - Cribbs, D. H. AU - Kim, R. C. AU - Maarouf, C. L. AU - Whiteside, C. M. AU - Kokjohn, T. A. PY - 2013 DA - 2013// TI - Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy JO - PLoS ONE VL - 8 UR - https://doi.org/10.1371/journal.pone.0059735 DO - 10.1371/journal.pone.0059735 ID - Roher2013 ER - TY - JOUR AU - Farlow, M. AU - Arnold, S. E. AU - Dyck, C. H. AU - Aisen, P. S. AU - Snider, B. J. AU - Porsteinsson, A. P. PY - 2012 DA - 2012// TI - Safety and biomarker effects of solanezumab in patients with Alzheimer’s disease JO - Alzheimers Dement VL - 8 UR - https://doi.org/10.1016/j.jalz.2011.09.224 DO - 10.1016/j.jalz.2011.09.224 ID - Farlow2012 ER - TY - JOUR AU - Doody, R. S. AU - Thomas, R. G. AU - Farlow, M. AU - Iwatsubo, T. AU - Vellas, B. AU - Joffe, S. PY - 2014 DA - 2014// TI - Phase 3 trials of solanezumab for mild-to-moderate Alzheimer’s disease JO - N Engl J Med VL - 370 UR - https://doi.org/10.1056/NEJMoa1312889 DO - 10.1056/NEJMoa1312889 ID - Doody2014 ER - TY - JOUR AU - Siemers, E. R. AU - Sundell, K. L. AU - Carlson, C. AU - Case, M. AU - Sethuraman, G. AU - Liu-Seifert, H. PY - 2016 DA - 2016// TI - Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer’s disease patients JO - Alzheimers Dement VL - 12 UR - https://doi.org/10.1016/j.jalz.2015.06.1893 DO - 10.1016/j.jalz.2015.06.1893 ID - Siemers2016 ER - TY - JOUR AU - Ostrowitzki, S. AU - Deptula, D. AU - Thurfjell, L. AU - Barkhof, F. AU - Bohrmann, B. AU - Brooks, D. J. PY - 2012 DA - 2012// TI - Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab JO - Arch Neurol VL - 69 UR - https://doi.org/10.1001/archneurol.2011.1538 DO - 10.1001/archneurol.2011.1538 ID - Ostrowitzki2012 ER - TY - JOUR AU - Lemere, C. A. AU - Lopera, F. AU - Kosik, K. S. AU - Lendon, C. L. AU - Ossa, J. AU - Saido, T. C. PY - 1996 DA - 1996// TI - The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology JO - Nat Med VL - 2 UR - https://doi.org/10.1038/nm1096-1146 DO - 10.1038/nm1096-1146 ID - Lemere1996 ER - TY - JOUR AU - Lopera, F. AU - Lopera, F. AU - Ardilla, A. AU - Martínez, A. AU - Madrigal, L. AU - Arango-Viana, J. C. PY - 1997 DA - 1997// TI - Clinical Features of Early-Onset Alzheimer Disease in a Large Kindred With an E280A Presenilin-1 Mutation//Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation JO - JAMA VL - 277 UR - https://doi.org/10.1001/jama.1997.03540340027028 DO - 10.1001/jama.1997.03540340027028 ID - Lopera1997 ER - TY - JOUR AU - Muhs, A. AU - Hickman, D. T. AU - Pihlgren, M. AU - Chuard, N. AU - Giriens, V. AU - Meerschman, C. PY - 2007 DA - 2007// TI - Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice JO - Proc Natl Acad Sci U S A VL - 104 UR - https://doi.org/10.1073/pnas.0703137104 DO - 10.1073/pnas.0703137104 ID - Muhs2007 ER - TY - JOUR AU - Adolfsson, O. AU - Pihlgren, M. AU - Toni, N. AU - Varisco, Y. AU - Buccarello, A. L. AU - Antoniello, K. PY - 2012 DA - 2012// TI - An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ JO - J Neurosci VL - 32 UR - https://doi.org/10.1523/JNEUROSCI.4742-11.2012 DO - 10.1523/JNEUROSCI.4742-11.2012 ID - Adolfsson2012 ER - TY - JOUR AU - Haass, C. AU - Schlossmacher, M. G. AU - Hung, A. Y. AU - Vigo-Pelfrey, C. AU - Mellon, A. AU - Ostaszewski, B. L. PY - 1992 DA - 1992// TI - Amyloid beta-peptide is produced by cultured cells during normal metabolism JO - Nature VL - 359 UR - https://doi.org/10.1038/359322a0 DO - 10.1038/359322a0 ID - Haass1992 ER - TY - JOUR AU - Niederwolfsgruber, E. AU - Schmitts, T. L. AU - Blasko, I. AU - Trieb, K. AU - Steger, M. M. AU - Maczek, C. PY - 1998 DA - 1998// TI - The Production of the Alzheimer Amyloid Precursor Protein (APP) in Extraneuronal Tissue Does Not Increase in Old Age JO - J Gerontol A Biol Sci Med Sci VL - 53 UR - https://doi.org/10.1093/gerona/53A.3.B186 DO - 10.1093/gerona/53A.3.B186 ID - Niederwolfsgruber1998 ER - TY - JOUR AU - Mawuenyega, K. G. AU - Sigurdson, W. AU - Ovod, V. AU - Munsell, L. AU - Kasten, T. AU - Morris, J. C. PY - 2010 DA - 2010// TI - Decreased clearance of CNS beta-amyloid in Alzheimer’s disease JO - Science VL - 330 UR - https://doi.org/10.1126/science.1197623 DO - 10.1126/science.1197623 ID - Mawuenyega2010 ER - TY - JOUR AU - Soscia, S. J. AU - Kirby, J. E. AU - Washicosky, K. J. AU - Tucker, S. M. AU - Ingelsson, M. AU - Hyman, B. PY - 2010 DA - 2010// TI - The Alzheimer’s disease-associated amyloid beta-protein is an antimicrobial peptide JO - PLoS ONE VL - 5 UR - https://doi.org/10.1371/journal.pone.0009505 DO - 10.1371/journal.pone.0009505 ID - Soscia2010 ER - TY - JOUR AU - Plant, L. D. AU - Boyle, J. P. AU - Smith, I. F. AU - Peers, C. AU - Pearson, H. A. PY - 2003 DA - 2003// TI - The production of amyloid beta peptide is a critical requirement for the viability of central neurons JO - J Neurosci VL - 23 ID - Plant2003 ER - TY - STD TI - Frost JL, Liu B, Shi Q, Kleinschmidt M, Demuth HU, Schilling S, Lemere CA. Passive and active pyroglutamate-3 Abeta (AbetaN3pE) immunotherapy in AD-like transgenic mouse models: Abstract Society for Neuroscience. 2010 ID - ref73 ER - TY - JOUR AU - Acero, G. AU - Manoutcharian, K. AU - Vasilevko, V. AU - Munguia, M. E. AU - Govezensky, T. AU - Coronas, G. PY - 2009 DA - 2009// TI - Immunodominant epitope and properties of pyroglutamate-modified Abeta-specific antibodies produced in rabbits JO - J Neuroimmunol VL - 213 UR - https://doi.org/10.1016/j.jneuroim.2009.06.003 DO - 10.1016/j.jneuroim.2009.06.003 ID - Acero2009 ER - TY - JOUR AU - Gardberg, A. S. AU - Dice, L. T. AU - Ou, S. AU - Rich, R. L. AU - Helmbrecht, E. AU - Ko, J. PY - 2007 DA - 2007// TI - Molecular basis for passive immunotherapy of Alzheimer’s disease JO - Proc Natl Acad Sci U S A VL - 104 UR - https://doi.org/10.1073/pnas.0705888104 DO - 10.1073/pnas.0705888104 ID - Gardberg2007 ER - TY - JOUR AU - Wirths, O. AU - Erck, C. AU - Martens, H. AU - Harmeier, A. AU - Geumann, C. AU - Jawhar, S. PY - 2010 DA - 2010// TI - Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis JO - J Biol Chem VL - 285 UR - https://doi.org/10.1074/jbc.M110.178707 DO - 10.1074/jbc.M110.178707 ID - Wirths2010 ER - TY - JOUR AU - Frost, J. L. AU - Liu, B. AU - Kleinschmidt, M. AU - Schilling, S. AU - Demuth, H. AU - Lemere, C. A. PY - 2012 DA - 2012// TI - Passive immunization against pyroglutamate-3 amyloid-β reduces plaque burden in Alzheimer-like transgenic mice: a pilot study JO - Neurodegener Dis VL - 10 UR - https://doi.org/10.1159/000335913 DO - 10.1159/000335913 ID - Frost2012 ER - TY - JOUR AU - Frost, J. L. AU - Liu, B. AU - Rahfeld, J. U. AU - Kleinschmidt, M. AU - O’Nuallain, B. AU - Le, K. X. PY - 2015 DA - 2015// TI - An anti-pyroglutamate-3 Abeta vaccine reduces plaques and improves cognition in APPswe/PS1DeltaE9 mice JO - Neurobiol Aging VL - 36 UR - https://doi.org/10.1016/j.neurobiolaging.2015.08.021 DO - 10.1016/j.neurobiolaging.2015.08.021 ID - Frost2015 ER - TY - BOOK AU - Crehan, H. AU - Rahfeld, J. U. AU - Cynis, H. AU - Le, K. X. AU - Kleinschmidt, M. AU - O’Nuallain, B. PY - 2015 DA - 2015// TI - Anti-pGlu Abeta mAb Ig isotype affects plaque clearance.: Abstract ID - Crehan2015 ER - TY - STD TI - Crehan H, Kleinschmidt M, Fitzpatrick E, Chowdhury S, Le KX, Frost JL, et al. Passive vaccination targeting pyroglutamate-3 Abeta reduces Abeta plaque burden without microhemorrhage and partially rescues cognitive deficits in aged APP/PS1/dE9 mice: Abstract. Soc Neurosci. 2015. ID - ref80 ER - TY - BOOK AU - Lemere, C. A. AU - Crehan, H. AU - Liu, B. AU - Kleinschmidt, M. AU - Rahfeld, J. U. AU - Fitzpatrick, E. PY - 2016 DA - 2016// TI - Phagocytic characterization and therapeutic efficacy of an anti-pyroglutamate-3 Abeta IgG2a antibody in aged APP/PS1dE9 mice: Abstract ID - Lemere2016 ER - TY - JOUR AU - Pfeifer, M. AU - Boncristiano, S. AU - Bondolfi, L. AU - Stalder, A. AU - Deller, T. AU - Staufenbiel, M. PY - 2002 DA - 2002// TI - Cerebral hemorrhage after passive anti-Abeta immunotherapy JO - Science VL - 298 UR - https://doi.org/10.1126/science.1078259 DO - 10.1126/science.1078259 ID - Pfeifer2002 ER - TY - JOUR AU - DeMattos, R. B. AU - Lu, J. AU - Tang, Y. AU - Racke, M. M. AU - Delong, C. A. AU - Tzaferis, J. A. PY - 2012 DA - 2012// TI - A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer’s disease mice JO - Neuron VL - 76 UR - https://doi.org/10.1016/j.neuron.2012.10.029 DO - 10.1016/j.neuron.2012.10.029 ID - DeMattos2012 ER - TY - JOUR AU - Hashimoto, T. AU - Wakabayashi, T. AU - Watanabe, A. AU - Kowa, H. AU - Hosoda, R. AU - Nakamura, A. PY - 2002 DA - 2002// TI - CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV JO - EMBO J VL - 21 UR - https://doi.org/10.1093/emboj/21.7.1524 DO - 10.1093/emboj/21.7.1524 ID - Hashimoto2002 ER -