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Table 1 Summary of preclinical results obtained by active and passive vaccination

From: Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges

Ag/Ab

AD Model

Treatment

Effect

Ref.

Active vaccination

pGlu-3 mimotope

Tg2576

Preventive

Reduced plaques

USPTO No.: 20110097351

pGlu-3-9-KLH

J20

Preventive

Reduced plaques

[73]

pGlu-3 Aβ42

Rabbit (WT)

-

-

[74]

Passive vaccination

9D5

5XFAD

Preventive

Reduced plaques and Aβ peptides

[76]

07/1

APP/PS1ΔE9

Preventive & Therapeutic

Reduced plaques; no change in Aβ peptides

[7780]

mE8

PDAPP

Therapeutic

No change in plaques; reduced Aβ peptides

[83]

  1. Ag Antigen, Ab Antibody, Ref. Reference, USPTO US Patent and Trademark Office