From: Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges
Ag/Ab | AD Model | Treatment | Effect | Ref. |
---|---|---|---|---|
Active vaccination | ||||
pGlu-3 mimotope | Tg2576 | Preventive | Reduced plaques | USPTO No.: 20110097351 |
pGlu-3-9-KLH | J20 | Preventive | Reduced plaques | [73] |
pGlu-3 Aβ42 | Rabbit (WT) | - | - | [74] |
Passive vaccination | ||||
9D5 | 5XFAD | Preventive | Reduced plaques and Aβ peptides | [76] |
07/1 | APP/PS1ΔE9 | Preventive & Therapeutic | Reduced plaques; no change in Aβ peptides | |
mE8 | PDAPP | Therapeutic | No change in plaques; reduced Aβ peptides | [83] |