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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: IKKβ-mediated inflammatory myeloid cell activation exacerbates experimental autoimmune encephalomyelitis by potentiating Th1/Th17 cell activation and compromising blood brain barrier

Fig. 8

Myeloid-specific ikkβ gene deletion reduces transferred EAE. a-b T-cells were isolated from lymph nodes of WT or LysM-Cre/Ikkβ F/F donor (n = 5 per group) at 15–18 days after induction of active EAE and re-stimulated with MOG35–55 peptide (25 μg/ml). Purified T cells (1 × 107) were transferred i.v. into sub-lethally irradiated WT or LysM-Cre/Ikkβ F/F recipient mice. Disease development was monitored daily (a) and cumulative disease index (b) was assessed. Experimental groups include Wild type → Wild type, Wild type → LysM-Cre/Ikkβ F/F, LysM-Cre/Ikkβ F/F → Wild type, and LysM-Cre/Ikkβ F/F → LysM-Cre/Ikkβ F/F. Data are represented as mean ± SEM. (ANOVA test; *p < 0.05 and **p < 0.01 versus Wild type → Wild type EAE mice)

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