Skip to main content

Table 1 Myeloid-specific ikkβ gene deletion ameliorates a subsequent encephalogenic challenge

From: IKKβ-mediated inflammatory myeloid cell activation exacerbates experimental autoimmune encephalomyelitis by potentiating Th1/Th17 cell activation and compromising blood brain barrier

 

Group

Incidence (%)

Mean day of onset (± SEM)

Maximal clinical score (± SEM)

Sun of clinical score (± SEM)

Mortality (%)

PBS

Wild type

3/3

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0

LysM-Cre/Ikkβ F/F

3/3

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

0

MOG

Wild type

7/7

7.6 ± 0.7

3.4 ± 0.2#

64.1 ± 1.7#

0

LysM-Cre/Ikkβ F/F

7/7

10.2 ± 0.5

2.6 ± 0.2*

17.3 ± 3.0*

0

  1. ANOVA test; *p < 0.05 versus WT EAE mice; #p < 0.05 versus normal control mice