Skip to main content

Table 1 Myeloid-specific ikkβ gene deletion ameliorates a subsequent encephalogenic challenge

From: IKKβ-mediated inflammatory myeloid cell activation exacerbates experimental autoimmune encephalomyelitis by potentiating Th1/Th17 cell activation and compromising blood brain barrier

  Group Incidence (%) Mean day of onset (± SEM) Maximal clinical score (± SEM) Sun of clinical score (± SEM) Mortality (%)
PBS Wild type 3/3 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0 0
LysM-Cre/Ikkβ F/F 3/3 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0 0
MOG Wild type 7/7 7.6 ± 0.7 3.4 ± 0.2# 64.1 ± 1.7# 0
LysM-Cre/Ikkβ F/F 7/7 10.2 ± 0.5 2.6 ± 0.2* 17.3 ± 3.0* 0
  1. ANOVA test; *p < 0.05 versus WT EAE mice; #p < 0.05 versus normal control mice