Fig. 5
From: Pim1 inhibition as a novel therapeutic strategy for Alzheimer’s disease
Pim1i decreases Aβ levels. Sandwich ELISA measurements of insoluble and soluble Aβ40 and Aβ42 levels in brain extracts from 3xTg-AD veh (n = 7) and 3xTg-AD Pim1i (n = 5) mice. a, b Soluble and insoluble Aβ42 levels were significantly lower in 3xTg-AD mice injected with Pim1i (Soluble Aβ40: t (10) =2.442, p < 0.05; insoluble Aβ40: t (10) = 2.681, p < 0.05). c, d Soluble and insoluble Aβ42 levels were significantly lower in 3xTg-AD mice treated with Pim1i (soluble Aβ42: t (10) = 2.404, p < 0.05; insoluble Aβ42: t (10) = 3.932, p < 0.01). Error bars represent mean ± SEM