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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer’s disease

Fig. 1

Multifactorial nature of AD and involvement of several different etiopathogenic mechanisms. Early-onset familial AD caused by mutations in APP, PS1, or PS2 constitutes < 1 % of AD cases. The exact causes of late-onset sporadic AD which accounts for the remaining > 99 % of AD cases are as yet largely unknown. However, aging alongside gene-environment interaction is speculated to contribute to this form of AD. Both forms of AD lead to amyloid plaque and neurofibrillary pathologies, synaptic dysfunction and neurodegeneration, and ultimately cognitive impairment

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Molecular Neurodegeneration

ISSN: 1750-1326